Widely regarded as one of the finest neo-gothic buildings in the United States, the Scottish Rite Cathedral is the largest building in the world devoted to freemasonry. It is owned by the Valley of Indianapolis Scottish Rite, an affiliated body of Freemasonry and was built between 1927 and 1929. It was built with every measurement being evenly divisible by three (reflecting the three degrees in Freemasonry), with many being divisible by 33 (reflecting the degrees a member of the Scottish Rite can achieve).

The main tower features a 54-bell carillon and rises 212 feet above Indianapolis. It also has a floating ballroom. Other features are patterned ceilings, ornate carved woodwork, and artistic stained-glass windows. The auditorium has 1200 seats, and has been called a beautiful testimony to craftsmanship. It also has a large pipe organ. The main entrance is known as the Tiler's Room, which is a perfect cube of 33 feet. It features both Masonic symbols and the signs of the Zodiac.

There are conducted tours on weekdays and every 3rd Saturday of a month.