On this site (along Istiklad Caddesi) a church seems to have been built in 1678. However, it repeatedly burned down, and the present church seems to be from 1789. The parish itself is older, stemming from 1453, near current Sirkeci station. After the conquest it was to move, and in the end came to this spot in Pera. It is a Franciscan church, an icon is claimed to be miraculous and to date from the first church in Constantinople.

I have a special (not exhaustive) gallery of Istanbul churches.