The Cosmopolitan Hotel, also known as La Casa de Bandini

This building, one of the oldest in San Diego, will re-open in June after an extensive renovation.
Personally I think a lot of the character and also architectural details were damaged or destroyed in the renovation.
You can see another similar photo taken in 1872 (when lenses were not so wide) of the building which began as a one story adobe here: Cosmopolitan Hotel