The area was settled by members of the Houmas tribe, who were later run out by the Tunica Indians.
The French established a settlement, Ste Reyne aux Tonicas, in 1729, but it did not last. The Spainsh claimed the area, but did not make use of it, their holdings were all west of the Mississippi River.

After Louisiana became a state, the area was divided into parts, west and east Feliciana parishes.

Situated along the Mississippi River, the area was subject to annual flooding, which still occurs. Lumber and tourism are it's economy, with the large Louisiana State Prison (Angola) too.

There are many historic places in West Feliciana, many are open as bed and breakfasts. There are many ante-bellum homes, the most notable, Rosedown and Oakley (Audubon State Park).

West Feliciana Parish remains a quite place, just up the river from the hustle and bustle of Baton Rouge.

For more information about West Feliciana Parish, see http://www.stfrancisville.us/?full=1