Colostethus is a large genus of poison dart frogs native to Central and South America. Unlike most members of the family Dendrobatidae, members of the genus Colostethus are not usually brightly colored or poisonous.

Colostethus is paraphyletic as presently delimited, because although all species have a common ancestor, not all species descended from that ancestor are included in Colostethus. Current evolutionary studies will likely result in splitting of Colostethus into segregate genera in the near future.