Bank of America Tower at One Bryant Park is a 1,200 ft (366 m) skyscraper in the Midtown district of Manhattan in New York City, in the United States. It is located on Sixth Avenue, between 42nd and 43rd Street, opposite Bryant Park.

The US$1 billion project was designed by Cook+Fox Architects to be one of the most efficient and ecologically friendly buildings in the world. It is the second tallest building in New York City, after the Empire State Building, and the fourth tallest building in the United States. Construction was completed in 2009.

In June 2010, the Bank of America Tower was the recipient of the 2010 Best Tall Building Americas award by the Council on Tall Buildings and Urban Habitat

The tower's architectural spire is 255.5 ft (77.9 m) tall and was placed on December 15, 2007.