From Antakya, 5th century. Within the medallion is the bust of Ktisis. Around it are animals and branches of pomegranate.
From several sources I understand she was the personification of ("creation" or "construction, building"). But as I had the second picture on for a while you can see some discussion about who she was.
Antakya Archaeology Museum Ktisis mosaic sept 2019 6218.jpg