The official dedication of the Basilica and the adjacent Lateran Palace was presided over by Pope Sylvester I in 324, declaring both to be Domus Dei or "House of God." In its interior, the Papal Throne was placed, making it the Cathedral of the Bishop of Rome. In reflection of the basilica's claim to primacy in the world as "mother church", the words Sacrosancta Lateranensis ecclesia omnium urbis et orbis ecclesiarum mater et caput (meaning "Most Holy Lateran Church, of all the churches in the city and the world, the mother and head") are incised in the front wall between the main entrance doors.
The Lateran Palace and basilica have been rededicated twice. Pope Sergius III dedicated them to Saint John the Baptist in the 10th century in honor of the newly consecrated baptistry of the Basilica. Pope Lucius II dedicated the Lateran Palace and basilica to Saint John the Evangelist in the 12th century. However, St. John Baptist and St. John the Evangelist are regarded as co-patrons of the Cathedral, the chief patron being Christ the Saviour himself, as the inscription in the entrance of the Basilica indicates