Completed in 2006 (replacing the original 1963 structure), the Guthrie cost an estimated $125,000,000. The award-winning design is the work of architect Jean Nouvel, along with the Minneapolis architectural firm Architectural Alliance. The Guthrie is a 285,000 square foot facility that houses three theaters: (1) the theater's signature thrust stage, seating 1,100, (2) a 700-seat proscenium stage, and (3) a black-box studio with flexible seating. It also has a 178-foot cantilevered bridge (called the "Endless Bridge") to the Mississippi which is open to visitors during normal building hours.

Please note that some of the windows are tinted blue or yellow. In particular the windows on the 9th floor observation floor, also known as "The Amber Box," are all tinted yellow, and thus the images below are the color as would be seen in person.