Francisco de Montejo y Alverez (c. 1479 in Salamanca – c. 1553 in Spain) was a Spanish conquistador in Mexico and Central America.

Francisco de Montejo left Spain in 1514, and arrived in Cuba in time to join Grijalva's expedition along the coast of Yucatán and the Gulf of Mexico. On his return to Cuba, he joined with Hernan Cortes and as part of that expedition, helped found the city of La Villa Rica de Vera Cruz (today Veracruz) in Mexico. Cortes then sent him as an envoy back to Spain in 1519 to report on the expedition.

In December 1526 the Spanish King, Carlos I, issued a royal decree naming Montejo Adelantado and Capitan General of Yucatán. He returned to Yucatán in 1528, and attempted to conquer it along the east coast (Tulum, Chetumal) but was driven back by the ferocity of the resistance of the Maya living along this coast. In 1530 he decided to try conquering Yucatán from the west, and began by pacifying what is today the modern Mexican state of Tabasco. From 1531-1535 he tried unsuccessfully to conquer western Yucatán, with some successes but in 1535 his forces were driven from Yucatán.