The Sinai was inhabited by the Monitu and was called Mafkat or Country of Turquoise. From the time of the First dynasty or before, the Egyptians mined turquoise in Sinai at two locations, now called by their Arabic names Wadi Maghareh and Serabit el-Khadim. The mines were worked intermittently and on a seasonal basis for thousands of years. Modern attempts to exploit the deposits have been unprofitable. These may be the first known mines.

The Mamluks of Egypt controlled the Sinai from 1260 until 1518, when the Ottoman Sultan, Selim the Grim, destroyed them at the Battles of Marj Dabiq and al-Raydaniyya. From then until the early 20th century, Sinai, as part of the Pashalik of Egypt, was under the control of the Ottoman Empire. In 1906 it became part of British-controlled Egypt, when the Turkish government yielded to British pressure to hand over the peninsula. The border imposed by the british runs in an almost straight line from Rafah on the Mediterranean shore to Taba on the Gulf of Aqaba. This line has served as the eastern border of Sinai ever since, and is now the international border between Israel and Egypt. St. Catherine's Monastery is the oldest monastery in the world and the most popular tourist